Stress management plays an important role in improving metabolic control in type 2 diabetes patients. https://www.selleckchem.com/products/pk11007.html The aim of this study was to find the effect of educational intervention on improving stress management in type 2 diabetic patients in Dezful, Iran.
In an experimental study, 92 patients with type 2 diabetes who were referred to the Diabetes Clinic of Ganjavian Hospital of Dezful were selected by available sampling method. Then, they were randomly divided into two groups 46 as intervention and 46 as control. For the intervention group, a stress management training program was designed for one month (8 sessions), while there was no training for the control group. All participants filled the Cohen Perceived Stress Questionnaire (PSQ) in baseline and follow up (3 months) phases. All the data were analyzed using SPSS software by conducting an independent t- test, and paired sample t- test, and Chi-square test at a significant level of 0.05.
The mean age of participants was 52.70 ± 10.91 years. Pre-test data revealed that there was no significant difference between the stresses of the two groups (P&gt; 0.05); however, the results of the independent t-test, 3 months after the educational intervention, demonstrated a significant decrease in stress level in the intervention group compared to the control group (P &lt;0.05).
Based on the findings of this study, it is concluded that the design and implementation of health education interventions can be useful to improve stress management in people with type 2 diabetes.
Based on the findings of this study, it is concluded that the design and implementation of health education interventions can be useful to improve stress management in people with type 2 diabetes.People with rheumatic disease may be at higher risk for more severe course with COVID- 19, and the adverse effects of drugs used to treat rheumatic diseases is a major concern.
We conducted this survey to learn about the real impact of COVID-19 pandemic on patients with rheumatic diseases.
Participants were asked to complete a questionnaire using a telephonic interview conducted by two rheumatologists. Rheumatic disease characteristics, knowledge and attitude toward COVID-19, and impacts of pandemic on rheumatology care and patient's compliance were assessed.
We included 307 patients in the survey, and rheumatoid arthris was the main rheumatic disease. Patients had mostly moderate level of knowledge about COVID-19, and patients with higher level of education were more likely to have better knowledge. Participants respected mainly recommended preventive measures. The pandemic and sanitary containment impacted strongly the rheumatology care. Over quarter of patients noted worsening of their rheumatic disease, two-thirds reported postponed or canceled medical apointments and more than three quarters postponed their laboratory tests. Patients with higher disease activity were more likely to have lack of follow-up. Medication change was noted in more than third of cases. It was mostly stopped, and DMARDs were mainly affected. Patients living in rural area and who had canceled, or postponed their appointments were more likely to change their treatment.
Our data are useful to better manage rheumatic patients. Physicians are encouraged to renew contact with their patients to insure medication compliance.
Our data are useful to better manage rheumatic patients. Physicians are encouraged to renew contact with their patients to insure medication compliance.To develop of anticancer active pharmaceutical intermediates.
Acridone derivatives possesses wide range of pharmacological activities1) intercalate DNA 2) form covalent bond with DNA.
To Screening of in vitro anticancer activity against Cdc25b and SHP1 of new acridone derivatives and preliminary study on structure-activity relationship.
Synthesis of new acridone derivatives and in vitro evaluation of their anticancer activity on Cdc25b and SHP1. Natural products that contain acridine structures, such as cystodytin A and acronycine, are isolated from certain marine (tunicates &amp; ascidians, sponges, sea anemones) and plant (bark of Australian scrub ash tree) species. Herein, we report the efficient one-pot green synthesis of twelve novel 3,4-dihydro-1 (2H) acridone derivatives, using montmorillonite K10 as the catalyst and iron/citric acid in water. Also, their inhibitory activity against Cdc25B and SHP1 is examined, in which specific derivatives show enhanced inhibitory activity compared to others.
Starting from 2-nitrobenzaldehyde derivatives and 1, 3-cyclohexanedione derivatives, twelve new acridone derivatives were prepared and exhibited substantial anticancer activity against Cdc25b and SHP1 cells.
Preliminary studies of the structure-activity relationship have shown the influence of the structural parameters and, in particular, the nature of the substituent on aromatic ring structure and cyclohexanone. Other Further study on structure-activity relationship.
Preliminary studies of the structure-activity relationship have shown the influence of the structural parameters and, in particular, the nature of the substituent on aromatic ring structure and cyclohexanone. Other Further study on structure-activity relationship.Recently, a sudden outbreak of novel coronavirus disease (COVID-19) was caused by a zoonotic virus known as severe acute respiratory syndrome coronavirus (SARS-CoV-2). It has caused pandemic situations around the globe and affecting the lives of millions of people. So far, no drug has been approved for the treatment of SARS-CoV-2 infected patients. As of now, more than 1000 clinical trials are going on for repurposing of FDA approved drugs and for evaluating the safety &amp; efficiency of experimental antiviral molecules to combat COVID-19. Since the development of new drugs may require months to years to reach the market, this review focusses on the potentials of existing small molecule FDA approved drugs and the molecules already in the clinical pipeline against viral infections like HIV, hepatitis B, Ebola virus, and other viruses of coronavirus family (SARS-CoV and MERS-CoV). The review also discusses the natural products and traditional medicines in clinical studies against COVID-19. Currently, 1978 studies are active, 143 completed and 4 posted results (as on June 13, 2020) on clinicaltrials.